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第三世代のBNA(2’,4’-BNANC)について

1.Abdur Rahman, S.M., Seki. S., Haitani. S., Miyashita, K., Imanishi.T. Highly Stable Pyrimidine-Motif Triplex Formation at Physiological pH Values by a Bridged Nculeci acid Analogues Angew. Chem. Int. Ed., 46, 4306-4309 (2007)

2.Abdur Rahman S.M., Seki, S., Yoshikawa, H., Miyashita, K., Imanishi, T. Design, Synthesis, and Properties of 2',4'-BNANC: A Bridged Nculeic acid Analogue J. Am. Chem. Soc., 130, 4886-4897 (2008)

3.Miyashita, K., Rahman, S.M., Seki, S., Obika, S., Imanishi, T. N-Methyl substituted 2’,4’-BNANC: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization Chem. Commun., 2007, 3765-3767 (2007)

4.Rahman, S.M., Seki, S., Utsuki, K., Obika, S., Miyashita, K, Imanishi, T. 2',4'-BNANC: A Novel Bridged Nucleic Acid Analogue with Excellent Hybridizing and Nuclease Resistance Profiles Nucleosides Nucleotides Nucleic Acids, 26, 1625-1628 (2007)

5.Abdur Rahman, S.M., Sato, H., Tsuda, N., Haitani, S., Narukawa, K., Imanishi, T., Obika, S. RNA interference with 2’,4’-bridged nucleic acid analogues Bioorg. Med. Chem., 18, 3474-3480 (2010)  20427190

6.Kuwahara, M., Obika, S., Nagashima, J., Ohta, Y., Suto, Y., Ozaki, H., Sawai, H., Imanishi, T. Systematic analysis of enzymatic DNA polymerization using oligo-DNA templates and triphosphate analogs involving 2’,4’-bridged nucleosides Nucleic Acids Res., 36, 4257-4265 (2008)  18583360

7.Kuwahara, M., Obika, S., Takashima, H., Hagiwara, Y., Nagashima, J., Ozaki, H., Sawai, H., Imanishi, T. Smart conferring of nuclease resistance to DNA by 3’-end protection using 2’,4’-bridged nucleoside-5’-triphosphates Bioorg. Med. Chem. Lett., 19, 2941-2943 (2009)  19414263

8.Torigoe, H., Abdur Rahman, S.M., Takuma, H., Sato, N., Imanishi, T., Obika, S., Sasaki, K. Interrupted 2’-O,4’-C-Aminomethylene Bridged Nucleic Acid Modification Enhances Pyrimidine Motif Triplex-Forming Ability and Nuclease Resistance Under Physiological Condition Nucleosides Nucleotides Nucleic Acids, 30, 63-81 (2011)  21259164

9.Torigoe, H., Abdur Rahman, S.M., Takuma, H., Sato, N., Imanishi, T., Obika, S. 2’-O,4’-C-Aminomethylene-Bridged Nucleic Acid Modification with Enhancement of Nuclease Resistance Promotes Pyrimidine Motif Triplex Nucleic Acid Formation at Physiological pH Chem. Eur. J., 17, 2742-51 (2011)  21264967

10.Kasahara, Y., Kitadume, S., Morihiro, K., Kuwahara, M., Ozaki, H., Swai, H., Imanishi, T., Obika, S. Effect of 3’-end capping of aptamer with various 2’,4’-bridged nucleotides: Enzymatic post-modification towards a practical use of polyclonal aptamers Bioorg. Med. Chem. Lett., 20, 1626-1629 (2010)  20153191

<Diagnostics and Researches(核酸検出)>

11.Shivarov, V., Ivanova, M., Naumova, E., Rapid Detection of DNMT3A R882 Mutations in Hematologic Malignancies Using a Novel Bead-Based Suspension Assay with BNA(NC) Probes PLOS ONE, 9, e99769 (2014)    24914952

<Therapeutics and Researches(核酸医薬)>

12.Yamamoto, T., Harada-Shiba, M., Nakatani, M., Wada, S., Yasuhara, H., Narukawa, K., Sasaki, K., Shibata, M., Torigoe, H., Yamaoka, T., Imanishi, T., Obika, S. Cholesterol-lowering Action of BNA-based Antisense Oligonucleotide Targeting PCSK9 in Atherogenic Diet-induced Hypercholesteromic Mice Mol. Ther. Nucleic Acids, 1, e22 (2012)  23344002

13.Prakash, T.P., Siwkowski, A., Allerson, C.R., Migawa, M.T., Lee, S., Gaus, J., Black, C., Seth, P.P., Swayze, E.E., Bhat, B. Antisense Oligonucleotides Containing Conformationally Constrained 2’,4’-(N-Methoxy)aminomethylene and 2’,4’-Aminoocymethylene and 2’-O,4’-C-Aminomethylene Bridged Nucleotide Analogues Show Improved Potency in Animal Models J. Med. Chem., 53, 1636-1650 (2010)  20108935

14.Yamamoto, T., Yasuhara, H., Wada, F., Marada-Shiba, M., Imanishi, T., Obika, S. Superior silencing by 2’,4’-BNANC-Based Short Antisense Oligonucleotides Compared to 2’,4’-BNA/LNA- Based Apolipoprotein B Antisense Inhibitors J. Nucleic Acids, 2012, ID 707323 (2012)

15.Kim SK, Castro A, Kim ES, Dinkel AP, Liu X, Castro M. Inhibitory Effect of Bridged Nucleosides on Thermus aquaticus DNA Polymerase and Insight into the Binding Interactions PLOS ONE, 11(1), e0147234 (2016)

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