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Literatures of 2',4'-BNANC

1. Abdur Rahman, S.M., Seki. S., Haitani. S., Miyashita, K., Imanishi.T.
•Highly Stable Pyrimidine-Motif Triplex Formation at Physiological pH Values by a Bridged Nculeci acid Analogues
Angew. Chem. Int. Ed., 2007, 46, 4306-4309

2. Abdur Rahman S.M., Seki, S., Yoshikawa, H., Miyashita, K., Imanishi, T.
•Design, Synthesis, and Properties of 2',4'-BNANC: A Bridged Nculeic acid Analogue
J. Am. Chem. Soc., 2008, 130, 4886-4897

3. Miyashita, K., Rahman, S.M., Seki, S., Obika, S., Imanishi, T.
N-Methyl substituted 2’,4’-BNANC: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization
Chem. Commun., 2007, 3765-3767

4. Rahman, S.M., Seki, S., Utsuki, K., Obika, S., Miyashita, K, Imanishi, T.
•2',4'-BNANC: A Novel Bridged Nucleic Acid Analogue with Excellent Hybridizing and Nuclease Resistance Profiles
Nucleosides Nucleotides Nucleic Acids, 2007, 26, 1625-1628

5. Abdur Rahman, S.M., Sato, H., Tsuda, N., Haitani, S., Narukawa, K., Imanishi, T., Obika, S.
•RNA interference with 2’,4’-bridged nucleic acid analogues
Bioorg. Med. Chem., 2010, 18, 3474-3480

6. Kuwahara, M., Obika, S., Nagashima, J., Ohta, Y., Suto, Y., Ozaki, H., Sawai, H., Imanishi, T.
•Systematic analysis of enzymatic DNA polymerization using oligo-DNA templates and triphosphate analogs involving 2’,4’-bridged nucleosides
Nucleic Acids Res., 2008, 36, 4257-4265

7. Kuwahara, M., Obika, S., Takashima, H., Hagiwara, Y., Nagashima, J., Ozaki, H., Sawai, H., Imanishi, T.
•Smart conferring of nuclease resistance to DNA by 3’-end protection using 2’,4’-bridged nucleoside-5’-triphosphates
Bioorg. Med. Chem. Lett., 2009, 19, 2941-2943

8. Torigoe, H., Abdur Rahman, S.M., Takuma, H., Sato, N., Imanishi, T., Obika, S., Sasaki, K.
•Interrupted 2’-O,4’-C-Aminomethylene Bridged Nucleic Acid Modification Enhances Pyrimidine Motif Triplex-Forming Ability and Nuclease Resistance Under Physiological Condition
Nucleosides Nucleotides Nucleic Acids, 2011, 30, 63-81

9. Torigoe, H., Abdur Rahman, S.M., Takuma, H., Sato, N., Imanishi, T., Obika, S.
•2’-O,4’-C-Aminomethylene-Bridged Nucleic Acid Modification with Enhancement of Nuclease Resistance Promotes Pyrimidine Motif Triplex Nucleic Acid Formation at Physiological pH
Chem. Eur. J., 2011, 17, 2742-51

10. Kasahara, Y., Kitadume, S., Morihiro, K., Kuwahara, M., Ozaki, H., Swai, H., Imanishi, T., Obika, S.
•Effect of 3’-end capping of aptamer with various 2’,4’-bridged nucleotides: Enzymatic post-modification towards a practical use of polyclonal aptamers
Bioorg. Med. Chem. Lett., 2010, 20, 1626-1629

<Diagnostics and Researches>

11. Shivarov, V., Ivanova, M., Naumova, E.
•Rapid Detection of DNMT3A R882 Mutations in Hematologic Malignancies Using a Novel Bead-Based Suspension Assay with BNA(NC) Probes
PLOS ONE, 2014, 9, e99769

<Therapeutics and Researches>

12. Yamamoto, T., Harada-Shiba, M., Nakatani, M., Wada, S., Yasuhara, H., Narukawa, K., Sasaki, K., Shibata, M., Torigoe, H., Yamaoka, T., Imanishi, T., Obika, S.
•Cholesterol-lowering Action of BNA-based Antisense Oligonucleotide Targeting PCSK9 in Atherogenic Diet-induced Hypercholesteromic Mice
Mol. Ther. Nucleic Acids, 2012, 1, e22

13. Prakash, T.P., Siwkowski, A., Allerson, C.R., Migawa, M.T., Lee, S., Gaus, J., Black, C., Seth, P.P., Swayze, E.E., Bhat, B.
•Antisense Oligonucleotides Containing Conformationally Constrained 2’,4’-(N-Methoxy)aminomethylene and 2’,4’-Aminooxymethylene and 2’-O,4’-C-Aminomethylene Bridged Nucleotide Analogues Show Improved Potency in Animal Models
J. Med. Chem., 2010, 53, 1636-1650

14. Yamamoto, T., Yasuhara, H., Wada, F., Marada-Shiba, M., Imanishi, T., Obika, S.
•Superior silencing by 2’,4’-BNANC-Based Short Antisense Oligonucleotides Compared to 2’,4’-BNA/LNA- Based Apolipoprotein B Antisense Inhibitors
J. Nucleic Acids, 2012, ID 707323

15. Kim SK, Castro A, Kim ES, Dinkel AP, Liu X, Castro M.
•Inhibitory Effect of Bridged Nucleosides on Thermus aquaticus DNA Polymerase and Insight into the Binding Interactions
PLOS ONE, 2016, 11(1), e0147234

16. Manning KS, Rao AN, Castro M, Cooper TA.
•BNANC Gapmers Revert Splicing and Reduce RNA Foci with Low Toxicity in Myotonic Dystrophy Cells
ACS Chem. Biol., 2017, 12, 2503–2509

17. Cromwell CR, Sung K, Park J, Krysler AR, Jovel J, Kim SK, Hubbard BP.
•Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity
Nature Communications, 2018, 9, 1448

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